In Stock: Pegfilgrastim – Biosimilars of Neulasta (Click Here)
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Prevention of Chemotherapy-Induced Neutropenia
– 6 mg SC once per chemotherapy cycle, beginning at least 24 hours after completion of chemotherapy
– Do not administer in the period between 14 days before and 24 hours after administration of cytotoxic chemotherapy.
Hematopoietic Radiation Injury Syndrome (Acute)
– 6 mg SC once weekly for 2 doses
Storage
– Store under refrigeration at 2°C to 8°C (36°F to 46°F)
– Do not freeze.
– If syringe for manual injection is inadvertently frozen, allow to thaw in refrigerator; discard if frozen more than one time
– Protect from light.
– Do not shake.
Pre-filled Syringe
– Allow prefilled syringe to reach room temperature for at least 30 minutes prior to injection
– Discard if kept at room temperature for longer than 48 hours
Monitoring
Chemotherapy-Induced Neutropenia
– Complete blood count (with differential) and platelet count should be obtained prior to chemotherapy and as clinically necessary.
Hematopoietic Radiation Injury Syndrome
– CBC at baseline (do not delay administration if CBC not readily available)
– Estimate absorbed radiation dose
– Evaluate fever, pulmonary infiltrates, and respiratory distress
– Evaluate for left upper abdominal pain, shoulder tip pain, or splenomegaly
– Monitor for signs/symptoms of glomerulonephritis (azotemia, hematuria, proteinuria) and capillary leak syndrome (hypotension, hypoalbuminemia, edema and hemoconcentration)
– Monitor for sickle cell crisis (in patients with sickle cell anemia)
