Description
Drug Info: ApoThera Drug Disease Clinical Support App
IV Administration
– Infuse over at least 1 hour; use of IV set with an in-line, low-protein binding filter (0.2 micrometer) required
– Do not infuse concomitantly in the same IV line with other agents
Reconstitution
– After calculating the appropriate dosage and volume of ustekinumab (using 130 mg per 26 mL vials), withdraw an equal volume of fluid from 250 mL bag of NS and discard
– Add to the NS bag; final volume of bag should be 250 mL
– Gently mix bag.
Storage
Intact Vials
– Refrigerate vials at 2°C to 8°C (36°F to 46°F)
– Do not freeze
– Store vials upright
– Keep the product in the original carton to protect from light until the time of use.
– Do not shake.
– Discard any unused portion
IV Infusion Solution
– Once diluted, solution for IV infusion may be stored up to 4 hours at room temperature (up to 25°C [77°F]).
Monitoring
– Tuberculosis screening (prior to initiating and periodically during therapy)
– CBC
– Ustekinumab-antibody formation
– Signs and symptoms of infection, reversible posterior leukoencephalopathy syndrome (RPLS), and squamous cell skin carcinoma
Related
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