Cimzia 200mg PreFilled Syringes SC Injection (Certolizumab Pegol 200mg PreFilled Syringes SC Injection)

– Bring to room temperature prior to administration

– After reconstitution (of vials), draw each vial into separate syringes (using 20-gauge needles).

– Administer subcutaneously (using provided 23-gauge needle) into the abdomen or thigh.

– For a 400 mg (2 syringes) dose, administer each 200 mg syringe at a separate site; rotate injection sites.

– Do not administer to areas where skin is tender, bruised, red, or hard.

– Latent TB screening prior to initiating and during therapy

– Signs/symptoms of infection (prior to, during, and following therapy)

– CBC with differential

– Signs/symptoms/worsening of heart failure

– HBV screening prior to initiating (all patients), HBV carriers (during and for several months following therapy)

– Signs and symptoms of hypersensitivity reaction

– Symptoms of lupus-like syndrome

– Signs/symptoms of malignancy (splenomegaly, hepatomegaly, abdominal pain, persistent fever, night sweats, weight loss) including periodic skin examinations.

– The American Gastroenterological Association suggests reactive therapeutic drug monitoring to guide treatment changes in adult patients treated with certolizumab for active inflammatory bowel disease