Drug Info: ApoThera Drug Disease Clinical Support App
Nirmatrelvir-Ritonavir (Paxlovid)
– 300 mg nirmatrelvir + 100 mg Ritonavir by mouth twice daily x 5 days
– Initiate as soon as possible after COVID-19 diagnosis and within 5 days of symptom onset
– Completing the full 5-day treatment course and isolate in accordance with public health recommendations are important to maximize viral clearance and minimize viral transmission
– If patient is hospitalized due to severe or critical COVID-19 after starting treatment with nirmatrelvir/ritonavir, completion of the full 5-day treatment is at the healthcare provider’s discretion
Missed Dose ≤8 hours
– Take missed dose as soon as possible, and resume normal dosing schedule
Missed Dose >8 hours
– Skip dose, and take the next dose at the regularly scheduled time
– Do not double dose to make up for missed dose
Contraception
– Use of ritonavir may reduce efficacy of combined hormonal contraceptives
– Advise patients using combined hormonal contraceptives to use an effective alternative contraceptive method or an additional barrier method of contraception
Limitations of Use
– Not authorized for initiation of treatment in patients requiring hospitalization owing to severe or critical COVID-19
– Not authorized for pre-exposure or post-exposure prophylaxis for prevention of COVID-19
– Not authorized for >5 consecutive days
