Diabetes Mellitus, Type 2
Initial Dose
– 2.5 mg SC every week x 4 weeks
Maintenance Dose
– Increase to 5 mg SC every week
– May increase by 2.5-mg increments after at least 4 weeks at current dose
Maximum Dose
– 15 mg SC every week
– 15 mg SC every week
Missed SC Dose
<4 Days (96 hour)
– Administer as soon as possible after missed dose
– Administer as soon as possible after missed dose
>4 days
– Skip missed dose and administer next dose on regularly scheduled day
– In each case, patients can resume their regular once weekly dosing schedule
– Skip missed dose and administer next dose on regularly scheduled day
– In each case, patients can resume their regular once weekly dosing schedule
Weight Management
Once Weekly SC Dose Escalation Schedule
– Weeks 1-4: 0.25 mg SC weekly
– Weeks 5-8: 0.5 mg SC weekly
– Weeks 9-12: 1 mg SC weekly
– Week 13-16: 1.7 mg SC weekly
Maintenance Dose
– Week 17 and onward: 2.4 mg SC weekly
– Initiate with low dose and gradually escalate to maintenance dose of 2.4 mg/week SC to minimize GI adverse reactions
– If unable to tolerate a dose during escalation, consider delaying dose escalation for 4 weeks
– If unable to tolerate maintenance dose of 2.4 mg once-weekly, may temporarily decreased to 1.7 mg once weekly, for a maximum of 4 weeks; after 4 weeks, increase back to maintenance 2.4 mg once-weekly; discontinue if not tolerated after second attempt
