Weight Management
Once Weekly SC Dose Escalation Schedule
– Weeks 1-4: 0.25 mg SC weekly
– Weeks 5-8: 0.5 mg SC weekly
– Weeks 9-12: 1 mg SC weekly
– Week 13-16: 1.7 mg SC weekly
Maintenance Dose
– Week 17 and onward: 2.4 mg SC weekly
– Initiate with low dose and gradually escalate to maintenance dose of 2.4 mg/week SC to minimize GI adverse reactions
– If unable to tolerate a dose during escalation, consider delaying dose escalation for 4 weeks
– If unable to tolerate maintenance dose of 2.4 mg once-weekly, may temporarily decreased to 1.7 mg once weekly, for a maximum of 4 weeks; after 4 weeks, increase back to maintenance 2.4 mg once-weekly; discontinue if not tolerated after second attempt
Manufacturer: Novo Nordisk
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SC Administration
– Administer SC to abdomen, thigh, or upper arm
– The time of day and the injection site can be changed without dose adjustment
– Administer once weekly, on the same day each week, at any time of day, with or without meals
– Visually inspect before use; drug should appear clear and colorless
– Do not use semaglutide if particulate matter and coloration observed
Storage
Intact SC Pens
– Refrigerate at 36-46ºF (2-8ºC)
– Do not store in freezer or directly adjacent to the refrigerator cooling element
– Do not freeze and do not use if frozen
After First SC Use
– Store at room temperature, 59-86°F (15-30°C) or refrigerate at 36-46ºF (2-8ºC) for up to 56 days
– Do not freeze
– Keep pen cap on when not in use
– Protect from excessive heat and sunlight
