Description
SC Administration
– Administer SC only
– Intended for use under supervision of a healthcare provider; patients may self-inject after training in SC injection technique
– Provide proper training on preparation and administration to patients and caregivers
Initial 600-mg Dose
– Administer each of the four 150-mg injections at different injection sites within the same body area
Subsequent 300-mg Doses
– Administer two 150-mg injections at different injection sites within the same body area
Site of Administration
– Thigh, abdomen (except for 2 inches [5 cm] around the navel), or upper arm if a caregiver is administering
– Rotate body area with each subsequent set of injections; do NOT inject into skin that is tender, damaged, bruised, or scarred
– Does not contain preservatives; discard any unused product remaining in prefilled syringe
SC Preparation
– Remove prefilled syringe from refrigerator and allow to reach room temperature (30 minutes) without removing needle cap
– Once removed from refrigerator, prefilled syringe may be kept at room temperature (≤25ºC [77ºF]) for up to 14 days
– Visually inspect for particulate matter and discoloration before administering; solution is clear-to-opalescent, colorless-to-pale yellow solution; discard if liquid contains visible particulate matter, is discolored, or is cloudy
Storage
Prefilled Syringes
– Does not contain preservatives; discard any unused product remaining in prefilled syringe
– Refrigerate at 2-8ºC (36-46ºF) in the original carton to protect from light
– If necessary, may be kept at room temperature ≤25ºC (77ºF) for up to 14 days in the original carton
– If carton needs to be removed permanently from refrigerator, record date of removal on outer carton in space provided
– After removal from refrigerator, use within 14 days or discard
– Do not expose to heat or direct sunlight
– Do not freeze; do not shake
