Avastin Single Dose Vials 100mg IV Injection (Bevacizumab Single Dose Vials 100mg IV Injection) | ApoThera – Concierge Specialty Pharmacy

– Infuse the initial dose over 90 minutes.

– The second infusion may be shortened to 60 minutes if the initial infusion is well tolerated.

– The third and subsequent infusions may be shortened to 30 minutes if the 60-minute infusion is well tolerated.

– After tolerance at the 90-, 60-, and 30-minute infusion rates has been established, some institutions use an off-label 10-minute infusion rate (0.5 mg/kg/minute) in adults for bevacizumab dosed at 5 mg/kg

– In a study evaluating the safety of the 0.5 mg/kg/minute infusion rate, proteinuria, and hypertension incidences were not increased with the shorter infusion time.

– Monitor closely during the infusion for signs/symptoms of an infusion reaction.

– Do not administer IV push or bolus.

– Do not administer with dextrose solutions.

– Temporarily withhold bevacizumab for 4 weeks prior to elective surgery and for at least 4 weeks (and until the surgical incision is fully healed) after surgery.