Description
Administration
– Administer with or without food
– Missed doses should be taken at their next regularly scheduled time
– For patients unable to swallow whole, tablets may be crushed and mixed with water to create a suspension for oral or NG use.
– If suspension is administered orally, refill glass with water, stir and drink; if administered via NG tube, flush NG tube through with water after administration
– Administration of crushed tablets, while bioequivalent to administration of whole tablets, may result in increased concentrations of ticagrelor and the major active metabolite at earlier time points
Storage
– Store at 25°C (77°F)
– Excursions permitted to 15°C to 30°C (59°F to 86°F)
Monitoring
– Signs of bleeding
– Hemoglobin and hematocrit periodically
– Renal function
– Uric acid levels (patients with gout or at risk of hyperuricemia)
– Signs/symptoms of dyspnea
