Description
SC Administration
– Vary/rotate injection site; choose site with adequate subcutaneous tissue (upper or mid-abdomen, upper buttocks) that does not have excessive pigment, nodules, lesions, or hair
– Avoid areas with brawny or fibrous tissues or areas that may be compressed or rubbed (belt or waistband).
– Administer within 30 minutes of preparation.
Reconstitution
– Packaged in two syringes; one contains the Atrigel polymer system and the second contains leuprolide acetate powder; follow package instructions for mixing
Storage
– Store at 2°C to 8°C (36°F to 46°F)
– Allow to reach room temperature prior to using
– Once outside the refrigerator, the kit may be stored (in its original packaging) at 15°C to 30°C (59°F to 86 °F) for up to 8 weeks prior to mixing and administration
– Once mixed, must be administered within 30 minutes (discard if not used within 30 minutes)
Monitoring
– LH and FSH levels, serum testosterone (~4 weeks after initiation of therapy)
– PSA
– Weakness, paresthesias, and urinary tract obstruction in first few weeks of therapy.
– Screen for diabetes (blood glucose and HbA1c) and cardiovascular risk prior to initiating and periodically during treatment
– Consider periodic monitoring of electrocardiograms and electrolytes.
