Gonal-F (Follitropin alfa) 900 IU Redi-Ject Pen SC Injection

–  Store the unused pen in the refrigerator.

– If necessary, the unused pen may also be stored at room temperature for up to 3 months.

– Once used, the pen may be stored in the refrigerator or at room temperature. Discard the used pen after 28 days

– Do not freeze.

– Protect from light

– Monitor sufficient follicular maturation

– This may be directly estimated by sonographic visualization of the ovaries and endometrial lining or measuring serum estradiol levels

– The combination of both ultrasonography and measurement of estradiol levels is useful for monitoring for the growth and development of follicles and timing hCG administration.

– The clinical evaluation of estrogenic activity (changes in vaginal cytology and changes in appearance and volume of cervical mucus) provides an indirect estimate of the estrogenic effect upon the target organs and, therefore, it should only be used adjunctively with more direct estimates of follicular development (ultrasonography and serum estradiol determinations).

– The clinical confirmation of ovulation is obtained by direct and indirect indices of progesterone production or by sonographic evidence. The indices of progesterone production most generally used are: urinary or serum luteinizing hormone (LH) rise, rise in basal body temperature, increase in serum progesterone, and menstruation following the shift in basal body temperature. The indices of sonographic evidence of ovulation include: Collapsed follicle, fluid in the cul-de-sac, features consistent with corpus luteum formation, or secretory endometrium.

– Monitor for signs and symptoms of ovarian hyperstimulation syndrome (OHSS) for at least 2 weeks following hCG administration

– Monitor for sufficient spermatogenesis. This can be directly estimated by semen analysis, or indirectly estimated by serum testosterone level.