Kyprolis 10 mg IV Injection (Amgen)

– Administer over 10 or 30 minutes depending on the carfilzomib dose regimen (see Dosing).

– Do not administer as an IV bolus.

– Hydrate with oral fluids (30 mL/kg) at least 48 hours prior to initiating cycle 1, as well as with 250 to 500 mL NS (or other appropriate IV fluid) prior to (recommended) and after (if needed) each dose in cycle 1; continue oral and/or IV hydration in subsequent cycles (if necessary).

– Flush line immediately before and after carfilzomib with NS or D5W.

– Do not administer with other medications.

– When administering as monotherapy, pre-medicate with dexamethasone 4 mg orally or IV when infusing carfilzomib over 10 minutes or with dexamethasone 8 mg orally or IV when infusing carfilzomib over 30 minutes.

– When using combination therapy, administer the recommended dexamethasone dose (refer to prescribing information).

– Pre-medicate 30 minutes to 4 hours prior to all doses in cycle 1, and as needed with future cycles to reduce the incidence and severity of infusion reaction.

– Store intact vials at 2°C to 8°C (36°F to 46°F)

– Store in original carton until use to protect from light

– Reconstituted drug (in the vial or in a syringe) and preparations diluted for infusion in D5W are stable for 4 hours at room temperature or for 24 hours refrigerated at 2°C to 8°C (36°F to 46°F).