Kyprolis 30 mg IV Injection (Amgen)

$1,975.00

Drug Info: ApoThera Drug Disease Clinical Support App

– Prescription Required
– Free Next Day Delivery to Anywhere in CA
– Free Same Day Delivery within 50-Mile Radius of ApoThera
– Concierge Pharmacy; Do NOT Accept Insurance
– Annual Concierge Pharmacy Membership Fee: $300/year
– Accept Credit Cards, Apple Pay and Zelle
– Do NOT accept manufacturer coupons
 
Physicians may send E-Prescriptions (E-Scripts) to:
ApoThera
45 Post, 2nd Floor
Irvine, CA 92618
Phone: (949)387-7711
Fax:      (949)387-7712
Multiple Myeloma (Relapsed/Refractory)
Single-Agent; 20-27 mg/m2 Regimen
Cycle 1
– 20 mg/m2 IV over 10 minutes on days 1 and 2
– If tolerated, increase dose to 27 mg/m2 IV over 10 minutes on days 8, 9, 15, and 16 of a 28-day treatment cycle
Cycles 2 to 12
– 27 mg/m2 IV over 10 minutes on days 1, 2, 8, 9, 15, and 16 of a 28-day treatment cycle
Cycle 13 and Beyond
– 27 mg/m2 IV over 10 minutes on days 1, 2, 15, and 16 of a 28-day treatment cycle
– Continue until disease progression or unacceptable toxicity
Single-Agent; 20-56 mg/m2 Regimen
Cycle 1
– 20 mg/m2 IV over 30 minutes on days 1 and 2
– If tolerated, increase dose to 56 mg/m2 over 30 minutes on days 8, 9, 15, and 16 of a 28-day treatment cycle
Cycles 2 to 12
– 56 mg/m2 IV over 30 minutes on days 1, 2, 8, 9, 15, and 16 of a 28-day treatment cycle.
Cycle 13 and Beyond
– 56 mg/m2 IV over 30 minutes on days 1, 2, 15, and 16 of a 28-day treatment cycle
– Continue until disease progression or unacceptable toxicity.
Find a Physician:
Manufacturer: Amgen
NDC: 76075010201 Category:

1 Vial = 1 Unit

Description

Drug Info: ApoThera Drug Disease Clinical Support App

IV Administration
– Administer over 10 or 30 minutes depending on the carfilzomib dose regimen (see Dosing).
– Do not administer as an IV bolus.
– Hydrate with oral fluids (30 mL/kg) at least 48 hours prior to initiating cycle 1, as well as with 250 to 500 mL NS (or other appropriate IV fluid) prior to (recommended) and after (if needed) each dose in cycle 1; continue oral and/or IV hydration in subsequent cycles (if necessary).
– Flush line immediately before and after carfilzomib with NS or D5W.
– Do not administer with other medications.
Pre-medication
– When administering as monotherapy, pre-medicate with dexamethasone 4 mg orally or IV when infusing carfilzomib over 10 minutes or with dexamethasone 8 mg orally or IV when infusing carfilzomib over 30 minutes.
– When using combination therapy, administer the recommended dexamethasone dose (refer to prescribing information).
– Pre-medicate 30 minutes to 4 hours prior to all doses in cycle 1, and as needed with future cycles to reduce the incidence and severity of infusion reaction.
Storage
Intact Vials
– Store intact vials at 2°C to 8°C (36°F to 46°F)
– Store in original carton until use to protect from light
Reconstituted Vials
– Reconstituted drug (in the vial or in a syringe) and preparations diluted for infusion in D5W are stable for 4 hours at room temperature or for 24 hours refrigerated at 2°C to 8°C (36°F to 46°F).
 
Monitoring
– CBC with differential and platelets (monitor frequently throughout therapy)
– Serum potassium levels regularly during treatment
– Renal function
– Pulmonary function (with new or worsening pulmonary symptoms)
– Liver function tests
– Blood pressure
– Signs/symptoms of infusion-related reactions, congestive heart failure, tumor lysis syndrome, peripheral neuropathy, posterior reversible encephalopathy syndrome, thrombocytopenic thrombotic purpura/hemolytic uremic syndrome, and venous thromboembolic events
– Monitor for evidence of volume overload due to pre- and post hydration.