Orencia (Abatacept) 125mg/mL Prefilled Syringe

– 125 mg SC once weekly

– Administer without an IV loading dose

– If transitioning from IV therapy to SC therapy, administer the first SC dose instead of the next scheduled IV dose.

– 125 mg SC once weekly

– SC dosing may be initiated with or without an IV loading dose.

– If initiating with an IV loading dose, administer the initial IV infusion (using the weight-based dosing), then administer 125 mg subcutaneously within 24 hours of the infusion, followed by 125 mg subcutaneously once weekly thereafter.

– If transitioning from IV therapy to SC therapy, administer the first SC dose instead of the next scheduled IV dose.

– Discontinue in patients who develop a serious infection

– IV Dosage according to Body Weight.

– Repeat dose at 2 weeks and 4 weeks after initial dose and every 4 weeks thereafter.

– 10 mg/kg

75 to 100 kg:  750 mg

>100 kg: 1,000 mg (maximum dose)

– Administer without an IV loading dose and use weight-based dosing

10 to <25 kg: 50 mg SC once weekly

≥25 to <50 kg: 87.5 mg SC once weekly

≥50 kg: 125 mg SC once weekly