Description
Drug Info: ApoThera Drug Disease Clinical Support App
Storage
Intact SC Pens
– Refrigerate at 36-46ºF (2-8ºC)
– Do not store in freezer or directly adjacent to the refrigerator cooling element
– Do not freeze and do not use if frozen
After First SC Use
– Store at room temperature, 59-86°F (15-30°C) or refrigerate at 36-46ºF (2-8ºC) for up to 56 days
– Do not freeze
– Keep pen cap on when not in use
– Protect from excessive heat and sunlight
Missed Dose
If Missed Dose is ≤5 days
– Administer dose as soon as possible
If Missed Dose >5 days
– Skip missed dose and administer next dose on the regularly scheduled day
– Patients can then resume their regular once weekly dosing schedule
SC Administration
– Administer SC to abdomen, thigh, or upper arm
– Administer once weekly, on the same day each week, at any time of the day, with or without meals
– Day of weekly administration can be changed if necessary as long as the time between 2 doses is at least 2 days (>48 hours)
– Use a different injection site each week when injecting in the same body region
– Visually inspect before use; drug should appear clear and colorless
– Do not use semaglutide if particulate matter and coloration observed
– When used with insulin, administer as separate injections and never mix the products; it is acceptable to inject semaglutide and insulin in the same body region but injections should not be adjacent to each other
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Side Effects
Very Common: may affect more than 1 in 10 people
• feeling or being sick (nausea or vomiting)
• diarrhea
• constipation
• stomach pain
• feeling weak or tired
• headache
– these usually goes away over time
• feeling or being sick (nausea or vomiting)
• diarrhea
• constipation
• stomach pain
• feeling weak or tired
• headache
– these usually goes away over time
Common: may affect up to 1 in 10 people
• feeling dizzy
• upset stomach or indigestion
• burping
• gas (flatulence)
• bloating of the stomach
• inflamed stomach (‘gastritis’) – the signs include stomach-ache, feeling sick (nausea) or
being sick (vomiting)
• reflux or heartburn – also called ‘gastro-esophageal reflux disease’
• hair loss
• injection site reactions
• low blood sugar (hypoglycaemia) in patients with diabetes
• low blood pressure
• increase of pancreatic enzymes (such as lipase) shown in blood tests
• hemorrhoids
• upset stomach or indigestion
• burping
• gas (flatulence)
• bloating of the stomach
• inflamed stomach (‘gastritis’) – the signs include stomach-ache, feeling sick (nausea) or
being sick (vomiting)
• reflux or heartburn – also called ‘gastro-esophageal reflux disease’
• hair loss
• injection site reactions
• low blood sugar (hypoglycaemia) in patients with diabetes
• low blood pressure
• increase of pancreatic enzymes (such as lipase) shown in blood tests
• hemorrhoids
Uncommon: may affect up to 1 in 100 people
• fast heartbeat
• increase of pancreatic enzymes (such as amylase) shown in blood tests
• feeling faint or fainting/passing out
• low blood sugar (hypoglycaemia) in patients without diabetes
• fast heartbeat
• increase of pancreatic enzymes (such as amylase) shown in blood tests
• feeling faint or fainting/passing out
• low blood sugar (hypoglycaemia) in patients without diabetes
Pregnancy and Breastfeeding
– Tell your doctor if you are pregnant, think you might be pregnant, or are planning to become pregnant.
– Tell your doctor if you are pregnant, think you might be pregnant, or are planning to become pregnant.
– Should not be used during pregnancy and for at least two months before a planned pregnancy because it is not known if it may affect your unborn child.
– If you could become pregnant while using Ozempic™, it is recommended to use contraception
– Do not use this medicine if you are breast-feeding, because it is not known if it passes into breast milk
Switching Between Ozempic (SC) and Rybelsus (Oral)
Taking 14 mg/day (Oral)
– Transition to 0.5 mg SC weekly on day after last oral dose
Taking 0.5 mg/week SC
– Transition to 7 mg or 14 mg by mouth starting up to 7 days after last SC injection
– There is no equivalent oral dose for the 1-mg SC dose
Find a Physician for Weight Loss or Diabetes (Ozempic 0.5mg):