Description
Drug Info: ApoThera Drug Disease Clinical Support App
SC Administration
– Warm by sitting at room temperature for 30 min; do NOT heat or microwave
– If multiple injections required, administer at different site on the body
– Warm by sitting at room temperature for 30 min; do NOT heat or microwave
– If multiple injections required, administer at different site on the body
– Injection sites: Front of thighs (recommended), lower abdomen (except for a 2-inch area right around the navel); back of the upper arms (only if someone else is administering it)
– Rotate injection sites for each administration
– Do not administer in area where the skin is tender, bruised, red, or hard
Storage
– Refrigerate Simponi at 36°F to 46°F (2°C to 8°C) in the original carton to protect from light until the time of use
– Do not freeze.
– Do not shake.
– Do not use Simponi beyond the expiration date (EXP) on the carton or the expiration date on the prefilled syringe (observed through the viewing window) or the prefilled SmartJect autoinjector.
– If needed, Simponi may be stored at room temperature up to 77°F (25°C) for a maximum single period of 30 days in the original carton to protect from light.
– Once a syringe or autoinjector has been stored at room temperature, do not return the product to the refrigerator.
– If not used within 30 days at room temperature, discard Simponi
Monitoring
– CBC with differential
– Latent TB screening (prior to initiating and periodically during therapy)
– HBV screening (prior to initiating [all patients]; during and for several months following therapy [HBV carriers])
– Monitor improvement of symptoms and physical function assessments
– Signs/symptoms of infection (prior to, during, and following therapy)
– Signs/symptoms/worsening of heart failure signs and symptoms of hypersensitivity reaction
– Symptoms of lupus-like syndrome
– Signs/symptoms of malignancy (splenomegaly, hepatomegaly, abdominal pain, persistent fever, night sweats, weight loss) including periodic skin examination
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