Description
Administration
– Administer doses ≥15 mg/day with food; dose of 10 mg/day may be administered without regard to meals.
– For nonvalvular atrial fibrillation, administer with the evening meal.
– For patients who cannot swallow whole tablets, the tablets (all strengths) may be crushed and mixed with applesauce immediately prior to use; immediately follow administration of the 15 mg and 20 mg tablets with food (10 mg tablets may be administered without regards to food).
Missed Doses
– Patients receiving 15 mg twice daily dosing who miss a dose should take a dose immediately to ensure 30 mg of rivaroxaban is administered per day (two 15 mg tablets may be taken together); resume therapy the following day as previously taken.
– Patients receiving once-daily dosing who miss a dose should take a dose as soon as possible on the same day; resume therapy the following day as previously taken.
Storage
– Store at 25°C (77°F)
– Excursions permitted to 15°C to 30°C (59°F to 86°F)
Monitoring
– CBC with differential
– Renal function prior to initiation, when clinically indicated, and at least annually
– Hepatic function
