Description
Drug Info: ApoThera Drug Disease Clinical Support App
IV Administration
– Infuse through a central line with a 0.2 micron polyethersulfone filter
– Infusion must be completed within 30 hours of reconstitution.
– Pre-medicate with a corticosteroid (dexamethasone 20 mg IV) 30 minutes prior to treatment
– Additional antiemetics may be needed.
Premedications
– Administer dexamethasone 20 mg IV 30 minutes prior to each infusion
– Trabectedin is associated with a moderate emetic potential
– Additional antiemetics may be necessary.
Storage
Intact Vials
– Store intact vials at 2°C to 8°C (36°F to 46°F)
IV Infusion Solutions
– Solutions diluted for infusion in NS or D5W should be used within 30 hours of reconstitution (infusion should be completed within that 30 hours)
Monitoring
– CBC with differential (baseline, prior to each dose, and periodically throughout treatment cycles)
– Total bilirubin (prior to each cycle, more frequently if clinically indicated), ALT, AST, and alkaline phosphatase (prior to each cycle; more frequently if clinically indicated)
– Renal function (baseline and during treatment)
– CPK (prior to each treatment cycle), evaluate LVEF via MUGA or echocardiogram (baseline and every 2 to 3 months)
– Monitor for signs/symptoms of capillary leak syndrome
– Monitor infusion site for signs/symptoms of extravasation
