{"id":15254,"date":"2023-11-17T14:37:51","date_gmt":"2023-11-17T22:37:51","guid":{"rendered":"https:\/\/store.apotheraspecialtypharmacy.com\/?post_type=product&p=15254"},"modified":"2025-10-16T13:59:50","modified_gmt":"2025-10-16T21:59:50","slug":"zepbound-tirzepatide-12-5mg-0-5ml-pre-filled-pens-injection","status":"publish","type":"product","link":"https:\/\/store.apotheraspecialtypharmacy.com\/?product=zepbound-tirzepatide-12-5mg-0-5ml-pre-filled-pens-injection","title":{"rendered":"Zepbound (Tirzepatide) 12.5mg\/0.5mL Pre-Filled Pens Injection"},"content":{"rendered":"

Drug Info: ApoThera Drug Disease Clinical Support App<\/a><\/strong><\/em><\/p>\n

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Storage<\/span><\/b><\/div>\n
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– Refrigerate at 2-8\u00baC (36-46\u00baF)
\n– If needed, each single-dose pen can be stored unrefrigerated at temperatures not to exceed 30\u00baC (86\u00baF) for up to 21 days
\n– Do not freeze
\n– Protect from light<\/div>\n<\/div>\n<\/div>\n<\/div>\n
Missed Dose<\/span><\/b><\/div>\n<\/div>\n
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<4 Days (96 hr)<\/strong><\/em>
\n– Administer as soon as possible after missed dose<\/div>\n
>4 days<\/strong><\/em>
\n– Skip missed dose and administer next dose on regularly scheduled day
\n– In each case, patients can resume their regular once weekly dosing schedule<\/div>\n
How Zepbound Works<\/span><\/b><\/div>\n
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SC Administration<\/span><\/b><\/div>\n
– Administer SC in abdomen, thigh, or upper arm
\n– Rotate injection site with each dose
\n– Administer once weekly, at any time of day, with or without meals
\n– Change day of weekly administration: May be changed, if necessary, as long as time between the 2 doses is at least 3 days (72 hr)<\/div>\n<\/div>\n
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SC Preparation<\/i><\/b><\/div>\n
– Inspect visually before use
\n– Solution should appear clear and colorless to slightly yellow; discard if particulate matter or discoloration observed<\/div>\n
The Most Common Side Effects<\/strong><\/span><\/b><\/div>\n<\/div>\n
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– Nausea<\/div>\n
– Diarrhea<\/div>\n
– Decreased appetite<\/div>\n
– Vomiting<\/div>\n<\/div>\n
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– Constipation<\/div>\n
– Indigestion<\/div>\n
– Stomach (abdominal) pain<\/div>\n
– The most common adverse reactions reported in \u22655% of Zepbound-treated patients in placebo-controlled trials were nausea, diarrhea, decreased appetite, vomiting, constipation, dyspepsia, and abdominal pain.<\/div>\n<\/div>\n<\/div>\n
Kidney Problems (Kidney Failure)<\/span><\/strong><\/span><\/b><\/div>\n
–\u00a0In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems to get worse<\/div>\n
– It is important for you to drink fluids to help reduce your chance of dehydration<\/div>\n
– Zepbound has been associated with gastrointestinal adverse reactions, which include nausea, vomiting, and diarrhea. These events may lead to dehydration, which if severe could cause acute kidney injury. In patients treated with GLP-1 receptor agonists, there have been post-marketing reports of acute kidney injury and worsening of chronic renal failure, sometimes requiring hemodialysis. Some of these events have been reported in patients without known underlying renal disease. A majority of reported events occurred in patients who had experienced nausea, vomiting, diarrhea, or dehydration. Monitor renal function when initiating or escalating doses of Zepbound in patients with renal impairment reporting severe adverse gastrointestinal reactions.<\/div>\n
Severe Stomach Problems<\/span><\/strong><\/span><\/b><\/div>\n
– Stomach problems, sometimes severe, have been reported in people who use Zepbound<\/div>\n
– Tell your healthcare provider if you have stomach problems that are severe or will not go away<\/div>\n
Changes in Vision<\/span><\/strong><\/span><\/b><\/div>\n
– Tell your healthcare provider if you have changes in vision during treatment with Zepbound.<\/div>\n
–\u00a0<\/span>Rapid improvement in glucose control has been associated with a temporary worsening of diabetic retinopathy.<\/div>\n
– Zepbound has not been studied in patients with non-proliferative diabetic retinopathy requiring acute therapy, proliferative diabetic retinopathy, or diabetic macular edema<\/div>\n
– Patients with a history of diabetic retinopathy should be monitored for progression of diabetic retinopathy.<\/div>\n
Gallbladder Problems<\/span><\/strong><\/span><\/b><\/div>\n
– Gallbladder problems have happened in some people who use Zepbound<\/div>\n
– In clinical trials, acute gallbladder disease was reported by 0.6% of Zepbound-treated patients and 0% of placebo-treated patients. If cholelithiasis is suspected, gallbladder diagnostic studies and appropriate clinical follow-up are indicated<\/div>\n
– Tell your healthcare provider right away if you get symptoms of gallbladder problems which may include:<\/div>\n
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