{"id":23532,"date":"2024-12-13T13:25:16","date_gmt":"2024-12-13T21:25:16","guid":{"rendered":"https:\/\/store.apotheraspecialtypharmacy.com\/?post_type=product&p=23532"},"modified":"2024-12-13T13:30:34","modified_gmt":"2024-12-13T21:30:34","slug":"kyprolis-10-mg-iv-injection-carfilzomib-10-mg-iv-injection","status":"publish","type":"product","link":"https:\/\/store.apotheraspecialtypharmacy.com\/?product=kyprolis-10-mg-iv-injection-carfilzomib-10-mg-iv-injection","title":{"rendered":"Kyprolis 10 mg IV Injection (Carfilzomib 10 mg IV Injection)"},"content":{"rendered":"

Drug Info: ApoThera Drug Disease Clinical Support App<\/em><\/a><\/strong><\/p>\n

\n
IV Administration<\/strong><\/span><\/b><\/div>\n
– Administer over 10 or 30 minutes depending on the carfilzomib dose regimen (see Dosing).<\/div>\n
– Do not administer as an IV bolus.<\/div>\n
– Hydrate with oral fluids (30 mL\/kg) at least 48 hours prior to initiating cycle 1, as well as with 250 to 500 mL NS (or other appropriate IV fluid) prior to (recommended) and after (if needed) each dose in cycle 1; continue oral and\/or IV hydration in subsequent cycles (if necessary).<\/div>\n
– Flush line immediately before and after carfilzomib with NS or D5W.<\/div>\n
– Do not administer with other medications.<\/div>\n
Pre-medication<\/i><\/strong><\/span><\/b><\/div>\n
– When administering as monotherapy, pre-medicate with dexamethasone 4 mg orally or IV when infusing carfilzomib over 10 minutes or with dexamethasone 8 mg orally or IV when infusing carfilzomib over 30 minutes.<\/div>\n
– When using combination therapy, administer the recommended dexamethasone dose (refer to prescribing information).<\/div>\n
– Pre-medicate 30 minutes to 4 hours prior to all doses in cycle 1, and as needed with future cycles to reduce the incidence and severity of infusion reaction.<\/div>\n<\/div>\n
<\/div>\n
Storage<\/strong><\/span><\/b><\/div>\n
\n
Intact Vials<\/i><\/b><\/div>\n
– Store intact vials at 2\u00b0C to 8\u00b0C (36\u00b0F to 46\u00b0F)<\/div>\n
– Store in original carton until use to protect from light<\/div>\n
Reconstituted Vials<\/i><\/b><\/div>\n
– Reconstituted drug (in the vial or in a syringe) and preparations diluted for infusion in D5W are stable for 4 hours at room temperature or for 24 hours refrigerated at 2\u00b0C to 8\u00b0C (36\u00b0F to 46\u00b0F).<\/div>\n
\u00a0<\/b><\/div>\n
Monitoring<\/strong><\/span><\/b><\/div>\n<\/div>\n
\n
\n
– CBC with differential and platelets (monitor frequently throughout therapy)<\/div>\n
– Serum potassium levels regularly during treatment<\/div>\n
– Renal function<\/div>\n
– Pulmonary function (with new or worsening pulmonary symptoms)<\/div>\n
– Liver function tests<\/div>\n
– Blood pressure<\/div>\n
– Signs\/symptoms of infusion-related reactions, congestive heart failure, tumor lysis syndrome, peripheral neuropathy, posterior reversible encephalopathy syndrome, thrombocytopenic thrombotic purpura\/hemolytic uremic syndrome, and venous thromboembolic events<\/div>\n
– Monitor for evidence of volume overload due to pre- and post hydration.<\/div>\n<\/div>\n<\/div>\n
\n
\n
<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Drug Info: ApoThera Drug Disease Clinical Support App<\/em><\/a><\/strong><\/p>\n

\n
\n
\n
\n
\u2013 Prescription Required<\/span><\/b><\/div>\n
\n
\n
\n
\n
\n
\n
\n
\u2013 Free Next Day Delivery to Anywhere in CA<\/span><\/b><\/div>\n
\u2013 Free Same Day Delivery within 50-Mile Radius of ApoThera<\/span><\/b><\/div>\n<\/div>\n
\u2013 Concierge Pharmacy; Do NOT Accept Insurance<\/span><\/b><\/div>\n
\u2013 Annual Concierge Pharmacy Membership Fee: $300\/year<\/span><\/b><\/div>\n
\n
\u2013 Accept Credit Cards, Apple Pay and Zelle<\/span><\/b><\/div>\n
\u2013 Do NOT\u00a0accept<\/strong>\u00a0manufacturer coupons<\/strong><\/span><\/b><\/div>\n
\u00a0<\/strong><\/b><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
Physicians may send E-Prescriptions (E-Scripts) to:<\/i>
\n<\/b><\/div>\n
\n
ApoThera<\/span><\/b><\/div>\n
45 Post, 2nd Floor<\/b><\/em><\/div>\n
Irvine, CA 92618<\/b><\/em><\/div>\n
Phone: (949)387-7711<\/b><\/em><\/div>\n
Fax:\u00a0 \u00a0 \u00a0\u00a0(949)387-7712<\/b><\/em><\/div>\n
<\/div>\n<\/div>\n<\/div>\n
Multiple Myeloma (Relapsed\/Refractory)<\/strong><\/span><\/b><\/div>\n
Single-Agent; 20-27 mg\/m2 Regimen<\/i><\/b><\/div>\n
Cycle 1<\/div>\n
– 20 mg\/m2 IV over 10 minutes on days 1 and 2<\/div>\n
– If tolerated, increase dose to 27 mg\/m2 IV over 10 minutes on days 8, 9, 15, and 16 of a 28-day treatment cycle<\/div>\n
Cycles 2 to 12<\/div>\n
– 27 mg\/m2 IV over 10 minutes on days 1, 2, 8, 9, 15, and 16 of a 28-day treatment cycle<\/div>\n
Cycle 13 and Beyond<\/div>\n
– 27 mg\/m2 IV over 10 minutes on days 1, 2, 15, and 16 of a 28-day treatment cycle<\/div>\n
– Continue until disease progression or unacceptable toxicity<\/div>\n
<\/div>\n
Single-Agent; 20-56 mg\/m2 Regimen<\/i><\/b><\/div>\n
Cycle 1<\/div>\n
– 20 mg\/m2 IV over 30 minutes on days 1 and 2<\/div>\n
– If tolerated, increase dose to 56 mg\/m2 over 30 minutes on days 8, 9, 15, and 16 of a 28-day treatment cycle<\/div>\n
Cycles 2 to 12<\/div>\n
– 56 mg\/m2 IV over 30 minutes on days 1, 2, 8, 9, 15, and 16 of a 28-day treatment cycle.<\/div>\n
Cycle 13 and Beyond<\/div>\n
– 56 mg\/m2 IV over 30 minutes on days 1, 2, 15, and 16 of a 28-day treatment cycle<\/div>\n
– Continue until disease progression or unacceptable toxicity.<\/div>\n
<\/div>\n
Find a Physician:<\/strong><\/div>\n
Hoag (Orange County)<\/a><\/strong><\/em><\/div>\n
Cedars Sinai (Los Angeles)<\/a><\/strong><\/em><\/div>\n
\n
Cottage Hospital Virtual Care (Santa Barbara)<\/a><\/strong><\/em><\/div>\n<\/div>\n
<\/div>\n
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Manufacturer:<\/strong>\u00a0Amgen<\/a><\/strong><\/em><\/div>\n<\/div>\n","protected":false},"featured_media":19670,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false},"product_cat":[183],"product_tag":[25990,8405,25992,25993,25989,25994,25995,25996,25997,25998,25999,26000,26001,26002,26003,26004,26005,26006,26007,26008,26009,26010,26011,26012,26013,26014,26015,26016,26017,26018,25991],"class_list":{"0":"post-23532","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-cancer","7":"product_tag-10-mg-kyprolis","8":"product_tag-https-store-apotheraspecialtypharmacy-com","9":"product_tag-kyprolis-10-availability","10":"product_tag-kyprolis-10-in-stock","11":"product_tag-kyprolis-10-mg","12":"product_tag-kyprolis-10-mg-availability","13":"product_tag-kyprolis-10-mg-in-stock","14":"product_tag-kyprolis-10-mg-in-stock-beverly-hills","15":"product_tag-kyprolis-10-mg-in-stock-brentwood","16":"product_tag-kyprolis-10-mg-in-stock-del-mar-heights","17":"product_tag-kyprolis-10-mg-in-stock-east-hampton","18":"product_tag-kyprolis-10-mg-in-stock-hamptons","19":"product_tag-kyprolis-10-mg-in-stock-la-jolla","20":"product_tag-kyprolis-10-mg-in-stock-laguna-beach","21":"product_tag-kyprolis-10-mg-in-stock-long-island","22":"product_tag-kyprolis-10-mg-in-stock-los-angeles","23":"product_tag-kyprolis-10-mg-in-stock-montecito","24":"product_tag-kyprolis-10-mg-in-stock-newport-beach","25":"product_tag-kyprolis-10-mg-in-stock-newport-coast","26":"product_tag-kyprolis-10-mg-in-stock-pacific-palisades","27":"product_tag-kyprolis-10-mg-in-stock-palos-verdes-peninsula","28":"product_tag-kyprolis-10-mg-in-stock-rancho-bernardo","29":"product_tag-kyprolis-10-mg-in-stock-rancho-palos-verdes","30":"product_tag-kyprolis-10-mg-in-stock-rancho-penasquitos","31":"product_tag-kyprolis-10-mg-in-stock-rancho-santa-fe","32":"product_tag-kyprolis-10-mg-in-stock-san-diego","33":"product_tag-kyprolis-10-mg-in-stock-san-francisco","34":"product_tag-kyprolis-10-mg-in-stock-santa-barbara","35":"product_tag-kyprolis-10-mg-in-stock-santa-monica","36":"product_tag-kyprolis-10-mg-in-stock-silicon-valley","37":"product_tag-kyprolis-10mg-availability","38":"wcpa_has_options","40":"first","41":"instock","42":"purchasable","43":"product-type-simple"},"jetpack-related-posts":[{"id":23536,"url":"https:\/\/store.apotheraspecialtypharmacy.com\/?product=kyprolis-30-mg-iv-injection-carfilzomib-30-mg-iv-injection","url_meta":{"origin":23532,"position":0},"title":"Kyprolis 30 mg IV Injection (Carfilzomib 30 mg IV Injection)","date":"December 13, 2024","format":false,"excerpt":"Drug Info: ApoThera Drug Disease Clinical Support App \u2013 Prescription Required \u2013 Free Next Day Delivery to Anywhere in CA \u2013 Free Same Day Delivery within 50-Mile Radius of ApoThera \u2013 Concierge Pharmacy; Do NOT Accept Insurance \u2013 Annual Concierge Pharmacy Membership Fee: $300\/year \u2013 Accept Credit Cards, Apple Pay\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":23534,"url":"https:\/\/store.apotheraspecialtypharmacy.com\/?product=kyprolis-60-mg-iv-injection-carfilzomib-60-mg-iv-injection","url_meta":{"origin":23532,"position":1},"title":"Kyprolis 60 mg IV Injection (Carfilzomib 60 mg IV Injection)","date":"December 13, 2024","format":false,"excerpt":"Drug Info: ApoThera Drug Disease Clinical Support App \u2013 Prescription Required \u2013 Free Next Day Delivery to Anywhere in CA \u2013 Free Same Day Delivery within 50-Mile Radius of ApoThera \u2013 Concierge Pharmacy; Do NOT Accept Insurance \u2013 Annual Concierge Pharmacy Membership Fee: $300\/year \u2013 Accept Credit Cards, Apple Pay\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4480,"url":"https:\/\/store.apotheraspecialtypharmacy.com\/?product=orencia-abatacept-125-mg-ml-pre-filled-syringes","url_meta":{"origin":23532,"position":2},"title":"Orencia (Abatacept) 125mg\/mL Clickjet Injection","date":"February 2, 2022","format":false,"excerpt":"Drug Info: ApoThera Drug Disease Clinical Support App Psoriatic Arthritis SC Dose - 125 mg SC once weekly - Administer without an IV loading dose - If transitioning from IV therapy to SC therapy, administer the first SC dose instead of the next scheduled IV dose. Rheumatoid Arthritis (RA) SC\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/store.apotheraspecialtypharmacy.com\/wp-content\/uploads\/2022\/02\/Orencia.125mg.mL_.ClickJet-3.jpg?fit=336%2C252&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":5501,"url":"https:\/\/store.apotheraspecialtypharmacy.com\/?product=orencia-abatacept-125-mg-ml-clickjet-injection","url_meta":{"origin":23532,"position":3},"title":"Orencia (Abatacept) 125mg\/mL Prefilled Syringe","date":"February 26, 2022","format":false,"excerpt":"Drug Info: ApoThera Drug Disease Clinical Support App Psoriatic Arthritis SC Dose - 125 mg SC once weekly - Administer without an IV loading dose - If transitioning from IV therapy to SC therapy, administer the first SC dose instead of the next scheduled IV dose. Rheumatoid Arthritis SC Dose\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/store.apotheraspecialtypharmacy.com\/wp-content\/uploads\/2022\/02\/Orencia.125mg.mL_.PFS-3.jpg?fit=305%2C232&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":6324,"url":"https:\/\/store.apotheraspecialtypharmacy.com\/?product=zinplava-bezlotoxumab-1000mg-40ml-injection","url_meta":{"origin":23532,"position":4},"title":"Zinplava (Bezlotoxumab) 1000mg\/40mL Injection","date":"March 15, 2022","format":false,"excerpt":"Drug Info: ApoThera Drug Disease Clinical Support App Clostridium Difficile Infection Adjunctive Therapy - 10 mg\/kg IV x 1 dose during antibacterial treatment for Clostridium difficile infection. - Repeat doses have not been studied Limitations of Use - To reduce recurrence of Clostridium difficile infection (CDI) in patients \u226518 years\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":5514,"url":"https:\/\/store.apotheraspecialtypharmacy.com\/?product=orencia-abatacept-250-mg-vial-iv","url_meta":{"origin":23532,"position":5},"title":"Orencia (Abatacept) 250mg\/Vial (IV)","date":"February 26, 2022","format":false,"excerpt":"Drug Info: ApoThera Drug Disease Clinical Support App Psoriatic Arthritis (IV Dose) - Dosing is according to body weight - Initial IV infusion (weight-based dosing) THEN, - Repeat IV infusion (the same weight-based dosing) at 2 weeks and 4 weeks after the initial infusion THEN, - Every 4 weeks thereafter.\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"_links":{"self":[{"href":"https:\/\/store.apotheraspecialtypharmacy.com\/index.php?rest_route=\/wp\/v2\/product\/23532","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/store.apotheraspecialtypharmacy.com\/index.php?rest_route=\/wp\/v2\/product"}],"about":[{"href":"https:\/\/store.apotheraspecialtypharmacy.com\/index.php?rest_route=\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/store.apotheraspecialtypharmacy.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23532"}],"version-history":[{"count":1,"href":"https:\/\/store.apotheraspecialtypharmacy.com\/index.php?rest_route=\/wp\/v2\/product\/23532\/revisions"}],"predecessor-version":[{"id":23533,"href":"https:\/\/store.apotheraspecialtypharmacy.com\/index.php?rest_route=\/wp\/v2\/product\/23532\/revisions\/23533"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/store.apotheraspecialtypharmacy.com\/index.php?rest_route=\/wp\/v2\/media\/19670"}],"wp:attachment":[{"href":"https:\/\/store.apotheraspecialtypharmacy.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23532"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/store.apotheraspecialtypharmacy.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_cat&post=23532"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/store.apotheraspecialtypharmacy.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_tag&post=23532"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}