{"id":6160,"date":"2022-03-11T11:24:36","date_gmt":"2022-03-11T19:24:36","guid":{"rendered":"https:\/\/store.apotheraspecialtypharmacy.com\/?post_type=product&p=6160"},"modified":"2025-02-18T13:57:46","modified_gmt":"2025-02-18T21:57:46","slug":"tysabri-natalizumab-300mg-15ml-injection","status":"publish","type":"product","link":"https:\/\/store.apotheraspecialtypharmacy.com\/?product=tysabri-natalizumab-300mg-15ml-injection","title":{"rendered":"Tysabri (Natalizumab) 300mg\/15mL Injection"},"content":{"rendered":"

Drug Info: ApoThera Drug Disease Clinical Support App<\/em><\/a><\/strong><\/p>\n

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IV Administration<\/strong><\/div>\n
– If stored under refrigeration, allow solution to warm to room temperature prior to administration.<\/div>\n
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– Diluted solution should be infused over 1 hour; do not administer by IV bolus or push.<\/div>\n
– Patients should be closely monitored for signs and symptoms of hypersensitivity during the infusion and for at least 1 hour after the infusion is complete.<\/div>\n
– The infusion should be discontinued if a reaction occurs, and treatment of the reaction should be instituted.<\/div>\n
– Following infusion, flush line with NS<\/div>\n
IV Reconstitution<\/b><\/div>\n
– Dilute natalizumab 300 mg in NS 100 mL to a final concentration of 2.6 mg\/mL<\/div>\n
– Gently invert to mix; do not shake<\/div>\n
\u00a0<\/b><\/div>\n
\u00a0<\/b>Storage<\/b><\/div>\n
– Store concentrated solution under refrigeration between 2\u00b0C to 8\u00b0C (36\u00b0F to 46\u00b0F)<\/div>\n
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– Do not freeze<\/div>\n
– Protect from light<\/div>\n
– Do not shake<\/div>\n
– Following dilution, may store refrigerated for use within 8 hours.<\/div>\n
\u00a0<\/b><\/div>\n
\u00a0<\/b>Monitoring<\/b><\/div>\n<\/div>\n
– Symptoms of hepatotoxicity (elevated serum transaminases, bilirubin)<\/div>\n
– Hypersensitivity reactions during, and for 1 hour after, infusion<\/div>\n
– Symptoms of persistent antibody-positivity (anxiety, dizziness, dyspnea, feeling cold, flushing, headache, hypertension, myalgia, nausea, pruritus, pyrexia, rigors, tachycardia, tremor, urticaria or, vomiting)<\/div>\n
– Signs\/symptoms of meningitis and encephalitis<\/div>\n
– Signs\/symptoms of acute retinal necrosis<\/div>\n
– Radiographic signs of PML periodically<\/div>\n
– Antibody testing is recommended if persistent antibodies are suspected and repeated in 3 months in all patients with documented positivity on initial test<\/div>\n
– Consider antibody testing in patients that resume therapy following a period of dosage interruption<\/div>\n
– Baseline brain MRI scan; if PML is suspected, obtain gadolinium-enhanced brain MRI scan and CSF analysis for JC viral DNA. Evaluate for signs or symptoms of progressive multifocal leukoencephalopathy during treatment and for 6 months after discontinuation<\/div>\n
– Transient and reversible leukocytosis (excluding neutrophils) and mildly reduced hemoglobin may occur with treatment and may require ~4 months for return to baseline values after the last dose; anti-JCV antibody (prior to therapy and periodically during therapy).<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Drug Info: ApoThera Drug Disease Clinical Support App<\/em><\/a><\/strong><\/p>\n

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Multiple Sclerosis<\/b><\/div>\n
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– 300 mg IV infused over 1 hour every 4 weeks<\/div>\n
Crohn Disease<\/b><\/div>\n
– 300 mg IV infused over 1 hour every 4 weeks<\/div>\n
– Discontinue if therapeutic benefit is not observed within initial 12 weeks of therapy<\/div>\n<\/div>\n
<\/div>\n
Find a Physician:<\/strong><\/div>\n
Hoag (Orange County)<\/a><\/strong><\/em><\/div>\n
Hoag Concierge Medicine (Newport Beach)<\/a><\/strong><\/em><\/div>\n
Hoag Urgent Care Telehealth<\/a><\/strong><\/em><\/div>\n
Shankle Clinic Neurology Specialists (Newport Beach)<\/a><\/strong><\/em><\/div>\n
Institute of Plant-Based Medicine (Newport Beach)<\/a><\/strong><\/em><\/div>\n
Cedars Sinai Virtual Care<\/a><\/strong><\/em><\/div>\n
Cedars Sinai (Los Angeles)<\/a><\/strong><\/em><\/div>\n
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Providence Telehealth<\/a><\/strong><\/em><\/div>\n
Cottage Hospital Virtual Care (Santa Barbara)<\/a><\/strong><\/em><\/div>\n
Scripps Virtual Care (San Diego)<\/a><\/strong><\/em><\/div>\n<\/div>\n<\/div>\n
<\/div>\n
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Manufacturer<\/b>:\u00a0Biogen<\/a><\/em><\/b><\/div>\n<\/div>\n
Tysabri Medication Guide<\/a><\/strong><\/em><\/div>\n<\/div>\n","protected":false},"featured_media":6161,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false},"product_cat":[189],"product_tag":[1231,489,321,312,419,311,892,320,874,360,364,488,491,361,362,881,319,318,490,1230],"class_list":{"0":"post-6160","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-monoclonal-antibody","7":"product_tag-64406-0008-01","8":"product_tag-biogen","9":"product_tag-cedars-sinai","10":"product_tag-clinical-decision-support-application","11":"product_tag-crohns-disease","12":"product_tag-drug-information","13":"product_tag-hoag-concierge-medicine","14":"product_tag-hoag-hospital","15":"product_tag-institute-of-plant-based-medicine","16":"product_tag-medicine-information","17":"product_tag-medicine-information-application","18":"product_tag-multiple-sclerosis","19":"product_tag-natalizumab","20":"product_tag-online-pharmacy","21":"product_tag-point-of-care-medical-application","22":"product_tag-shankle-clinic-neurology-specialists","23":"product_tag-telehealth","24":"product_tag-telemedicine","25":"product_tag-tysabri","26":"product_tag-tysabri-natalizumab-300mg-15ml-injection","27":"wcpa_has_options","29":"first","30":"instock","31":"purchasable","32":"product-type-simple"},"jetpack-related-posts":[{"id":6324,"url":"https:\/\/store.apotheraspecialtypharmacy.com\/?product=zinplava-bezlotoxumab-1000mg-40ml-injection","url_meta":{"origin":6160,"position":0},"title":"Zinplava (Bezlotoxumab) 1000mg\/40mL Injection","date":"March 15, 2022","format":false,"excerpt":"Drug Info: ApoThera Drug Disease Clinical Support App Clostridium Difficile Infection Adjunctive Therapy - 10 mg\/kg IV x 1 dose during antibacterial treatment for Clostridium difficile infection. - Repeat doses have not been studied Limitations of Use - To reduce recurrence of Clostridium difficile infection (CDI) in patients \u226518 years\u2026","rel":"","context":"Similar post","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":21318,"url":"https:\/\/store.apotheraspecialtypharmacy.com\/?product=cinqair-100-mg-injection-reslizumab-100-mg-injection","url_meta":{"origin":6160,"position":1},"title":"Cinqair 100 mg Injection (Reslizumab 100 mg Injection)","date":"October 3, 2024","format":false,"excerpt":"Drug Info: ApoThera Drug Disease Clinical Support App \u2013 Prescription Required \u2013 Free Next Day Delivery to Anywhere in CA and NY \u2013 Free Same Day Delivery within 50-Mile Radius of ApoThera \u2013 Concierge Pharmacy; 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