– 225 units SC once daily beginning on cycle day 2 or 3
– Menotropins may be administered together with urofollitropin and the total initial dose of both products combined should not exceed 225 units (menotropins 150 units and urofollitropin 75 units; or menotropins 75 units and urofollitropin 150 units)
– Dose should be adjusted after 5 days based on ultrasound monitoring of ovarian response and/or measurement of serum estradiol levels
– Do not make additional adjustments more frequently than once every 2 days or by >150 units
Maximum Daily Dose
– 450 units (of menotropins, or menotropins plus urofollitropin)
– Treatment >20 days is not recommended
– Once adequate follicular development is evident, hCG should be administered
– Withhold the hCG dose if ovarian monitoring suggests an increased risk of ovarian hyperstimulation syndrome
