Description
IV Administration
– For IV infusion only
– Allow diluted solution to reach room temperature
– Use an infusion set with an in-line, low protein-binding filter (pore size: 0.2 micron); compatible filters are polyethersulfone (PES), polyvinylidene fluoride (PVDF), nylon, and cellulose acetate
– Infuse over 20 to 50 minute period (may vary depending on total volume being infused) and then flush the IV administration set with NS after the infusion is finished
– Do not administer as an IV push or bolus and do not infuse concomitantly in the same IV line with other agents
– Observe patient during and for an appropriate time following infusion.
IV Reconstitution
– Remove vial from refrigerator; to minimize foaming, do not shake.
– Solution is clear to slightly hazy/opalescent, colorless to slight yellow liquid; proteinaceous particles may be present in the solution that appear translucent to white; do not administer if discolored
– Withdraw calculated volume from vial and, to minimize foaming, add slowly to 50 mL NS infusion bag
– Gently invert the bag; do not shake
– Compatible bags are polyvinylchloride (PVC) or polyolefin
– The time between preparation and administration should not exceed 16 hours
– Do not mix with other drugs.
– Vials are single-use only; discard unused portion.
Storage
Intact Vials
– Store intact vials in refrigerator at 2°C to 8°C (36°F to 46°F)
– Do not freeze or shake
– Protect from light
– Store in original package
IV Infusion Solutions
– After dilution in NS in infusion bag, administer immediately or store in a refrigerator at 2°C to 8°C (36°F to 46°F) or at room temperature up to 25°C (77°F)
– Protected from light, for up to 16 hours.
Monitoring
– Anaphylaxis/hypersensitivity reactions (during and after infusion)
– Peak flow, and/or other pulmonary function tests
– Monitor for signs of infection
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